Polymer-drug conjugates: idea and implementation

Polymer-drug conjugates include polymer prodrugs, PEGylated biomolecules, and antibody-drug conjugates

Today I want to talk about polymer-drug conjugates. What’s the idea behind such conjugates? What are the advantages and challenges? And are there any polymer-drug conjugates in clinical use?

I became interested in this topic during my PhD, as I was developing a polymer carrier material for ocular use. Since my carrier should be water-soluble, conjugation was the best way to incorporate drugs into the formulation. The concept of polymer-drug conjugates had already been described in the 1970s,[1] but hadn’t really been pursued in ocular drug delivery. Here, I will highlight some advantages of this technology and if you are interested to learn more, you can read my PhD thesis here.
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Transformative businesses and my definition of success

group's hand fist bump over desk with several laptops
Figure 1. Happiness at the workplace as a measure for success. Link

A few weeks ago I happened to attend a workshop on transformative entrepreneurship. During the summer I had started to volunteer for the Helsinki-based not-for-profit organization The Shortcut. The Shortcut supports tech startups by bringing people with different backgrounds together. They organize a multitude of events and trainings, for example an annual series of workshops, called School of Startups.

I was helping with the registrations during the School of Startups and whenever there was nothing else to do, I could participate in the sessions. This is how I found myself in this particular workshop about transformative entrepreneurship, which was really quite interesting and philosophical. The speaker was Sampsa Fabritius, CEO and founder of Kieku (an artificial intelligence powered podcast radio), and he started by asking us how we define success.

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